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1

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth

Journal:

Year:

2013

Language:

english

File:

PDF, 1.93 MB

english, 2013

2

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes by Plasmodium falciparum

Lin, Clara S., Uboldi, Alessandro D., Marapana, Danushka, Czabotar, Peter E., Epp, Christian, Bujard, Hermann, Taylor, Nicole L., Perugini, Matthew A., Hodder, Anthony N., Cowman, Alan F.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 3.03 MB

english, 2014

3

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

Ke, Francine F.S., Vanyai, Hannah K., Cowan, Angus D., Delbridge, Alex R.D., Whitehead, Lachlan, Grabow, Stephanie, Czabotar, Peter E., Voss, Anne K., Strasser, Andreas

Journal:

Year:

2018

Language:

english

File:

PDF, 16.59 MB

english, 2018

4

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P 2 position of PEXEL peptidomimetics

Nguyen, William, Hodder, Anthony N., de Lezongard, Richard Bestel, Czabotar, Peter E., Jarman, Kate E., O'Neill, Matthew T., Thompson, Jennifer K., Jousset Sabroux, Helene, Cowman, Alan F., Boddey, Ju

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

5

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Erinna F. Lee, Jack D. Sadowsky, Brian J. Smith, Peter E. Czabotar, Kimberly J. Peterson-Kaufman, Peter M. Colman, Samuel H. Gellman, W. Douglas Fairlie

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 962 KB

english, 2009

6

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Erinna F. Lee, Jack D. Sadowsky, Brian J. Smith, Peter E. Czabotar, Kimberly J. Peterson-Kaufman, Peter M. Colman, Samuel H. Gellman, W. Douglas Fairlie

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 962 KB

english, 2009

7

BCL-2 family antagonists for cancer therapy

Lessene, Guillaume, Czabotar, Peter E., Colman, Peter M.

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 841 KB

english, 2008

8

Molecular biology of Bax and Bak activation and action

Dana Westphal, Grant Dewson, Peter E. Czabotar, Ruth M. Kluck

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 1012 KB

english, 2011

9

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason, Cassandra J. Vandenberg, Lin Chen, Peter E. Czabotar, Simon N. Willis, Clare L. Scott, Catherine L. Day, Suzanne Cory, Jerry M. Adams, Andrew W. Rober

Journal:

Year:

2006

Language:

english

File:

PDF, 1.10 MB

english, 2006

10

Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1

Callum Smits, Peter E. Czabotar, Mark G. Hinds, Catherine L. Day

Journal:

Year:

2008

Language:

english

File:

PDF, 2.10 MB

english, 2008

11

IDENTIFICATION OF REGIONS WITHIN THE THIRD FnIII-LIKE DOMAIN OF THE IL-5Rα INVOLVED IN IL-5 INTERACTION

Peter E Czabotar, John Holland, Colin J Sanderson

Journal:

Year:

2000

Language:

english

File:

PDF, 737 KB

english, 2000

12

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Sudhir R. Dommaraju, Con Dogovski, Peter E. Czabotar, Lilian Hor, Brian J. Smith, Matthew A. Perugini

Journal:

Archives of Biochemistry and Biophysics

Year:

2011

Language:

english

File:

PDF, 893 KB

english, 2011

13

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

Jian-Guo Zhang, Peter E. Czabotar, Antonia N. Policheni, Irina Caminschi, Soo San Wan, Susie Kitsoulis, Kirsteen M. Tullett, Adeline Y. Robin, Rajini Brammananth, Mark F. van Delft, Jinhua Lu, Lorrain

Journal:

Year:

2012

Language:

english

File:

PDF, 1.53 MB

english, 2012

14

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

Grant Dewson, Tobias Kratina, Peter Czabotar, Catherine L. Day, Jerry M. Adams, Ruth M. Kluck

Journal:

Year:

2009

Language:

english

File:

PDF, 968 KB

english, 2009

15

Identification of residues involved in binding of IL5 to βcom using βIL3 and βcom chimeras

Peter E Czabotar, John Holland, Colin J Sanderson

Journal:

Year:

1999

Language:

english

File:

PDF, 168 KB

english, 1999

16

Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence

Peter E Czabotar, Stephen R Martin, Alan J Hay

Journal:

Year:

2004

Language:

english

File:

PDF, 209 KB

english, 2004

17

Structure-guided design of a selective BCL-XL inhibitor

Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, P

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

18

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X L

Sleebs, Brad E., Kersten, Wilhemus J. A., Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M., Parisot, John P., Yang, Hong, Czabotar, Peter E., Fairlie, W. Douglas, Lee, Erinn

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.94 MB

english, 2013

19

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E., Czabotar, Peter E., Fairbrother, Wayne J., Fairlie, W. Douglas, Flygare, John A., Huang, David C. S., Kersten, Wilhelmus J. A., Koehler, Michael F. T., Lessene, Guillaume, Lowes, Kym,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.81 MB

english, 2011

20

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Czabotar, Peter E., Lessene, Guillaume, Strasser, Andreas, Adams, Jerry M.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2013

Language:

english

File:

PDF, 1.74 MB

english, 2013

21

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel

Journal:

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

22

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

Yao, Shenggen, Westphal, Dana, Babon, Jeffrey J., Thompson, Geoff V., Robin, Adeline Y., Adams, Jerry M., Colman, Peter M., Czabotar, Peter E.

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 2.99 MB

english, 2014

23

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

Okamoto, Toru, Segal, David, Zobel, Kerry, Fedorova, Anna, Yang, Hong, Fairbrother, Wayne J., Huang, David C. S., Smith, Brian J., Deshayes, Kurt, Czabotar, Peter E.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 209 KB

english, 2014

24

Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity

Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M., Park, Chang H., Boghaert, Erwin R., Catron, Nathaniel D., Chen, Jun, Colman, Peter M., Czabotar, Peter E., Deshayes, Kurt, Fairbrot

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.57 MB

english, 2014

25

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Brouwer, Jason M., Westphal, Dana, Dewson, Grant, Robin, Adeline Y., Uren, Rachel T., Bartolo, Ray, Thompson, Geoff V., Colman, Peter M., Kluck, Ruth M., Czabotar, Peter E.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.40 MB

english, 2014

26

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

Okamoto, Toru, Zobel, Kerry, Fedorova, Anna, Quan, Clifford, Yang, Hong, Fairbrother, Wayne J., Huang, David C. S., Smith, Brian J., Deshayes, Kurt, Czabotar, Peter E.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.26 MB

english, 2013

27

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Westphal, Dana, Dewson, Grant, Menard, Marie, Frederick, Paul, Iyer, Sweta, Bartolo, Ray, Gibson, Leonie, Czabotar, Peter E., Smith, Brian J., Adams, Jerry M., Kluck, Ruth M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

28

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Hodder, Anthony N, Sleebs, Brad E, Czabotar, Peter E, Gazdik, Michelle, Xu, Yibin, O'Neill, Matthew T, Lopaticki, Sash, Nebl, Thomas, Triglia, Tony, Smith, Brian J, Lowes, Kym, Boddey, Justin A, Cowma

Journal:

Nature Structural and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.06 MB

english, 2015

29

Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly

Knoblich, Konstantin, Park, Soohyung, Lutfi, Mariam, van ’t Hag, Leonie, Conn, Charlotte E., Seabrook, Shane A., Newman, Janet, Czabotar, Peter E., Im, Wonpil, Call, Matthew E., Call, Melissa J.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.78 MB

english, 2015

30

A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation

Erinna F. Lee, Peter E. Czabotar, Mark F. van Delft, Ewa M. Michalak, Michelle J. Boyle, Simon N. Willis, Hamsa Puthalakath, Philippe Bouillet, Peter M. Colman, David C. S. Huang and W. Douglas Fairli

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 2.52 MB

english, 2008

31

A tale of two domains - a structural perspective of the pseudokinase, MLKL

Czabotar, Peter E., Murphy, James M.

Journal:

Year:

2015

Language:

english

File:

PDF, 693 KB

english, 2015

32

Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes

Lin, Clara S., Uboldi, Alessandro D., Epp, Christian, Bujard, Hermann, Tsuboi, Takafumi, Czabotar, Peter E., Cowman, Alan F.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.86 MB

english, 2016

33

Bcl-2 Family Proteins as Therapeutic Targets

E. Czabotar, Peter, Lessene, Guillaume

Journal:

Current Pharmaceutical Design

Year:

2010

Language:

english

File:

PDF, 427 KB

english, 2010

34

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

Birkinshaw, Richard W., Czabotar, Peter E.

Journal:

Seminars in Cell & Developmental Biology

Year:

2017

Language:

english

File:

PDF, 920 KB

english, 2017

35

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

Davies, Katherine A., Tanzer, Maria C., Griffin, Michael D. W., Mok, Yee Foong, Young, Samuel N., Qin, Rui, Petrie, Emma J., Czabotar, Peter E., Silke, John, Murphy, James M.

Journal:

Cell Death & Differentiation

Year:

2018

Language:

english

File:

PDF, 3.88 MB

english, 2018

36

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

Bandala-Sanchez, Esther, G. Bediaga, Naiara, Goddard-Borger, Ethan D., Ngui, Katrina, Naselli, Gaetano, Stone, Natalie L., Neale, Alana M., Pearce, Lesley A., Wardak, Ahmad, Czabotar, Peter, Haselhors

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 835 KB

english, 2018

37

Ensemble Properties of Bax Determine Its Function

Robin, Adeline Y., Iyer, Sweta, Birkinshaw, Richard W., Sandow, Jarrod, Wardak, Ahmad, Luo, Cindy S., Shi, Melissa, Webb, Andrew I., Czabotar, Peter E., Kluck, Ruth M., Colman, Peter M.

Journal:

Year:

2018

Language:

english

File:

PDF, 4.34 MB

english, 2018

38

The Structural Basis of Necroptotic Cell Death Signaling

Petrie, Emma J., Czabotar, Peter E., Murphy, James M.

Journal:

Trends in Biochemical Sciences

Year:

2018

Language:

english

File:

PDF, 3.30 MB

english, 2018

39

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Bernardini, Jonathan P, Brouwer, Jason M, Tan, Iris KL, Sandow, Jarrod J, Huang, Shuai, Stafford, Che A, Bankovacki, Aleksandra, Riffkin, Christopher D, Wardak, Ahmad Z, Czabotar, Peter E, Lazarou, Mi

Journal:

The EMBO Journal

Year:

2018

Language:

english

File:

PDF, 1.44 MB

english, 2018

40

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Blombery, Piers, Birkinshaw, Richard W., Nguyen, Tamia, Gong, Jia-nan, Thompson, Ella R., Xu, Zhen, Westerman, David A., Czabotar, Peter E., Dickinson, Michael, Huang, David C.S., Seymour, John F., Ro

Journal:

British Journal of Haematology

Year:

2019

Language:

english

File:

PDF, 436 KB

english, 2019

41

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins

Moldoveanu, Tudor, Czabotar, Peter E.

Journal:

Cold Spring Harbor Perspectives in Biology

Year:

2019

Language:

english

File:

PDF, 3.28 MB

english, 2019